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OCR: pressin The principal sites of biosynthesis of va ones of theand oxytocin are the magnocellular neu After supraoptic and paraventricular nuclei (5 s granules, packaging, the peptides are transported ils in the by axoplasmic flow, to the nerve termin ed directly posterior pituitary where they are releas into the circulation to act as classical neurohormones on distant target sites. See later: · Biochemistry of Neurohypophysial Neurosecretion